Irisu may refer to:
- Makina Irisu, one of the main characters of the Grisaia series.
- Kiyoka Irisu, Makina's mother.
- Masataka Irisu, Makina's late father.
- Sarina Irisu, Makina's younger half-sister.
- The Irisu Clan, a family that controls many parts of Japan from the shadows. The clan's current leader is Kiyoka.